Mammalian Aging Clocks and Epigenetic Life Span Variation
Investigates how DNA methylation patterns across mammalian species serve as molecular clocks for biological aging, revealing epigenetic mechanisms underlying the vast diversity in mammalian life spans.
Knowledge Graph (33 nodes, 296 connections)
Concept (4) →
life span variation
The diversity in maximum life spans across mammalian species, ranging from months to over 200 years.
epigenetic clock
Age estimator based on DNA methylation levels that uses penalized regression to relate chronological age to methylation levels of individual cytosines
DNA methylation
A small chemical modification that occurs in most cytosines that are followed by a guanine (CpGs) in mammalian genomes, serving as an epigenetic marke...
cytosine methylation
Protocol (2) →
Pan-mammalian DNA methylation microarray profiling (Muridae)
A microarray-based approach to profile DNA methylation at conserved CpG sites across diverse mammalian species without requiring species-specific refe...
Epigenetic pacemaker (Sciuridae)
Development of species-specific epigenetic clocks using cross-mammalian methylation arrays and elastic-net penalized regression to predict chronologic...